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manuscript (eg, employment/af

fi

liation, grants or funding, consultan-

cies, honoraria, stock ownership or options, expert testimony, royalties,

or patents

fi

led, received, or pending), are the following: None.

Funding/Support and role of the sponsor:

Orion Corporation (Finland)

and Bayer (Germany) funded personnel and equipment costs for this

study.

Acknowledgments:

The authors wish to thank Mary Bowden and Virginia

Yago who helped performing the in vivo studies.

Appendix A. Supplementary data

Supplementary material related to this article can be

found, in the online version, at

http://dx.doi.org/10.1016/j. eururo.2017.08.012

.

References

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