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stratification and clinical decision making for selected
patients with newly diagnosed disease.
Author contributions: Stephen K. Van Den Eeden had full access to all the
data in the study and takes responsibility for the integrity of the data and
the accuracy of the data analysis.
Study concept and design: Van Den Eeden, Quesenberry, Zhang, Lawrence,
Febbo, Presti.
Acquisition of data: Han, Tsiatis, Shan, Leimpeter, Zhang, Presti.
Analysis and interpretation of data: Van Den Eeden, Lu, Zhang, Shan,
Lawrence, Febbo, Presti.
Drafting of the manuscript: Van Den Eeden, Lawrence, Lu, Febbo, Presti.
Critical revision of the manuscript for important intellectual content: Van
Den Eeden, Lu, Lawrence, Febbo, Quesenberry, Presti.
ce:italic>Statistical analysis: Lu, Zhang [1_TD$DIFF], Quesenberry, Shan.
Obtaining funding: None.
Administrative, technical, or material support: Van Den Eeden, Lawrence.
Supervision: Van Den Eeden, Lawrence.
Other: None.
Financial disclosures: Stephen K. Van Den Eeden certifies that all
conflicts of interest, including speci fic financial interests and relation-
ships and affiliations relevant to the subject matter or materials
discussed in the manuscript (eg, employment/affiliation, grants or
funding, consultancies, honoraria, stock ownership or options, expert
testimony, royalties, or patents filed, received, or pending), are the
following: Stephen K. Van Den Eeden received funding from Genomic
Health Inc. to conduct this study. He has received research support from
Abbott Molecular and the National Institutes of Health. Ruixiao Lu is a
full-time employee of and has stock in Genomic Health, Inc. Nan Zhang
was a full-time employee of and has stock in Genomic Health, Inc.
Charles P. Quesenberry Jr, received salary support for this study from the
research grant from Genomic Health Inc. He has received research
support from the National Institutes of Health. Jun Shan received salary
support for this study from the research grant from Genomic Health Inc.
Jeong S. Han received salary support for this study from the research
grant from Genomic Health Inc. Athanasios C. Tsiatis is a full-time
employee of and has stock in Genomic Health, Inc. Amethyst D.
Leimpeter received salary support for this study from the research grant
fromGenomic Health Inc. H. Jeffrey Lawrence is a paid consultant for and
has stock in Genomic Health, Inc. Phillip G. Febbo is a full-time employee
of and has stock in Genomic Health, Inc. Joseph C. Presti received salary
support for this study from the research grant from Genomic Health Inc.
Funding/Support and role of the sponsor: This study was sponsored by
Genomic Health, Inc., which was involved in the design and conduct of
the study; collection, management, analysis, and interpretation of the
data; and preparation, review, and approval of the manuscript. Genomic
Health, Inc. performed the genomic testing and analyses described and
provided financial support to KPNC.
Acknowledgements: The authors acknowledge Agnes Nemeth, Kevin
Chew, Hargita Kaplan, Cindy Loman, Greg Jones, Rahul Peethala, Kenny
Wong, Dejan Knezevic, Aditi Dedhia, Rory O’Brien, and Keith Gran from
Genomic Health, Inc. and Daniel Fernandez, Deborah Burman, Judith
Morse, Erica Kereszi, and Marilyn Foley at KPNC for their logistical and
technical support, and Emily Burke for providing assistance in the
preparation of the manuscript.
Appendix A. Supplementary data
Supplementary data associated with this article can be
found, in the online version, at
.
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