134 148
Table 2
–
GPS prediction of clinical end points in uni- and multivariable analyses
Distant metastasis
Variable
N
HR
HR 95% CI
p
value
GPS per 20 units
259
2.75
(1.63, 4.63)
0.0002
Model
Variable
N
HR
95% CI
p
value
1
GPS per 20 units
259
2.00
(1.20
–
3.33)
0.007
Central Bx Gleason
3 + 4 vs 6
7.11
(1.48
–
34.21)
0.014
4 + 3 vs 6
7.79
(1.43-42.49)
0.018
8 + vs 6
19.37
(3.38-111.06)
0.001
2
GPS per 20 units
257
2.34
(1.42
–
3.86)
<
0.001
NCCN risk group
0.064
NCCN high vs very low and low
11.02
(1.44
–
84.29)
0.021
NCCN intermediate vs very low and low
5.70
(0.83
–
39.05)
0.076
3
GPS per 20 units
257
2.51
(1.49
–
4.23)
<
0.001
AUA risk group
0.109
AUA intermediate vs low
5.53
(0.75
–
40.73)
0.093
AUA high vs low
7.83
(1.14
–
53.65)
0.036
4
GPS per 20 units
257
2.63
(1.58
–
4.36)
<
0.001
CAPRA score
1.23
(1.00
–
1.52)
0.050
PCD
Variable
N
HR
HR 95% CI
p
value
GPS per 20 units
259
3.23
(1.84
–
5.65)
<
0.0001
Model
Variable
N
HR
95% CI
p
value
1
GPS per 20 units
257
2.69
(1.50
–
4.82)
<
0.001
NCCN risk group
0.017
NCCN high vs very low and low
22.54
(2.38
–
213.07)
0.007
NCCN intermediate vs very low and low
8.59
(1.06
–
69.56)
0.044
2
GPS per 20 units
257
3.04
(1.79
–
5.18)
<
0.001
AUA risk group
0.013
AUA intermediate vs low
7.12
(0.83
–
61.40)
0.074
AUA high vs low
16.79
(1.99
–
141.78)
0.010
3
GPS per 20 units
257
3.40
(2.04
–
5.64)
<
0.001
CAPRA score
1.76
(1.37
–
2.26)
<
.001
4
GPS per 20 units
242
2.58
(1.39
–
4.79)
0.003
Age at diagnosis
1.10
(1.02
–
1.18)
0.013
Central Bx Gleason
3 + 4 vs 6
1.86
(0.41
–
8.38)
0.419
4 + 3 vs 6
6.88
(1.48
–
32.06)
0.014
8 + vs 6
7.64
(1.33
–
43.80)
0.023
Percent of positive biopsy cores
11.18
(1.89
–
69.48)
0.008
PSA at diagnosis
1.01
(1.004
–
1.02)
0.001
BCR
Variable
N
HR
95% CI
p
value
GPS per 20 units
259
2.50
(1.62, 3.85)
<
0.0001
Model
Variable
N
HR
HR 95% CI
p
value
1
GPS per 20 units
257
2.11
(1.41
–
3.14)
<
0.001
NCCN risk group
<
0.001
NCCN high vs very low and low
5.21
(1.84
–
14.79)
0.002
NCCN intermediate vs very low and low
1.68
(0.61
–
4.65)
0.318
2
GPS per 20 units
257
2.41
(1.64
–
3.54)
<
0.001
AUA risk group
0.061
AUA intermediate vs low
1.53
(0.52
–
4.45)
0.439
AUA high vs low
2.74
(0.97
–
7.75)
0.058
3
GPS per 20 units
257
2.30
(1.58
–
3.36)
<
0.001
CAPRA score
1.56
(1.31
–
1.85)
<
0.001
4
GPS per 20 units
257
1.96
(1.28-3.03)
0.002
Clinical T stage
T2 vs T1
0.81
(0.42
–
1.57)
0.533
T3 vs T1
12.17
(4.89
–
30.30)
<
0.001
Central Gleason
3 + 4 vs 6
2.20
(0.88
–
5.53
0.094
4 + 3 vs 6
4.85
(1.90
–
12.36)
0.001
E U R O P E A N U R O L O GY 7 3 ( 2 0 18 ) 1 2 9
–
13 8
134