101 148
Table 5 (
Continued
)
Study
(1st author, yr)
No. of
nephrectomies
Arms (Nb)
Oncological outcomes
Histological outcomes
Follow-up
a(yr)
Free time to
transplantation
(yr)
Recommendations concerning waiting
period & prognostic factors of
recurrence, according to authors of the
included studies
Cancer
recurrence
Cancer
speci
fi
c
survival (time)
Overall
survival
(time)
Stage (%)
Grade (%)
Histologic
subtype (%)
5 yr
>
5 yr
Denton, 2002
[24]
11
I (11)
0% NS 100% (1
–
5 yr)
100% (1
–
5 yr)
pT1N0M0 100% Low 63%
High 37%
CRCC 60%
PRCC 45%
ChRCC 9%
2.6 1.9
0
- Waiting period:
- No waiting period for low T stage
and low grade RCC
- 36% of contralateral tumour on
postoperative imagery
Shingleton, 1998
[37]
4
C (4)
0% 0% 100% (
>
5 yr)
86% (1
–
5 yr)
pT1 100%
NS
CRCC 50%
PRCC 50%
(1
–
9)
NS
Kojima, 2006
[33]
44
C (44)
9% NS 98% (1
–
5 yr)
98% (1
–
5 yr)
pT1 97.7%
pT2 2.3%
N1 2.3%
Low 100% CRCC 84%
PRCC 8%
ChRCC 8%
3.9 (0.5
–
10)
NR
- Prognostic factor of recurrence:
tumour stage
- 9% of recurrence even with pT1
–
2
low grade
Shrewsberry, 2014
[31]
95
C (95)
3% 12% 88% (1-5 yr)
74% (1
–
5 yr)
pT1 82%
pT2 4%
pT3 9%
N+ 6%
Low 51%
High 49%
CRCC 65%
PRCC 32%
ChRCC 2%
ColDRCC 1%
1.9
NR
- Prognostic factor of recurrence:
- Clear cell subtype
- Lymphovascular invasion
Gigante, 2012
[16]303
C (90)
NS 48% 77% (
>
5 yr)
NS
pT1-2 86%
pT3
–
4 15%
N1 6%
Low 66%
High 34%
CRCC 77%
PRCC 22%
ChRCC 1%
3 (0.1
–
23)
NR
- Prognostic factor of cancer speci
fi
c
death:
- T stage
Hora, 2009
[32]
19
C (14)
0% NS 93% (1
–
5 yr)
86% (1
–
5 yr)
pT1 84%
pT3a 11%
pT3aN2 5%
NS
CRCC 68%
PRCC 22%
Liposarcoma 5%
1.6 (0.3
–
4.5)
NR
- 21% combination of CRCC and PRCC
- Do not recommend systematic
contralateral nephrectomy before
transplantation
Peces, 2004
[34]
8
C (8)
0% NS 75% (1
–
5 yr)
75% (1
–
5 yr)
pT1-2 75%
pT3N0 12%
pT3M1 12%
Low 88%
High 12%
CRCC 63%
PRCC 37%
3.5 (0
–
20)
NR
- Prognosis of time under dialysis on
histological outcomes:
- Multifocal tumour
- PRCC
Stiles, 2003
[35]
404
C (404)
NS NS NS
12% (1-5years) NS
NS
NS
2.1 1.2
NR
- Patients with CKD/dialysis owing to
nephrectomy for RCC had the same
survival as patients under dialysis
for other reason (diabetes)
Gulanikar, 1998
[36]
8
C (8)
0% NS 100% (1-5years) 100% (1-5years) pT1a 100%
NS
CRCC 14%
PRCC 88%
1.2 (0.4
–
2.8)
NR
- 25% of bilateral RCC
-Do not recommend systematic
contralateral nephrectomy before
transplantation
C = control (dialysis); ChRCC = chromophobe renal cell carcinoma; CKD = chronic kidney disease; CRCC = clear renal cell carcinoma; ColDRCC = collecting duct renal cell carcinoma; HR = hazard ratio; I = intervention (renal
transplantation); N = not stated; NR = not relevant (for noncomparative studies with one control arm); PRCC = papillary renal cell carcinoma.
a
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